Updates in osteogenesis imperfecta
Zeitlin, L.; Wientroub, S.; Blumberg, N.
Harefuah 142(10): 688-93 717
2003
ISSN/ISBN: 0017-7768 PMID: 14565069 Document Number: 555121
Osteogenesis Imperfecta, a heterogenous group of inherited disorders, is characterized by both bone fragility and low bone mass. Since the Sillence classification of the disease, significant progress has been made in understanding the molecular, histological and genetical pathogenesis of the disease, and it led to expanded nosology. The multidisciplinary approach including rehabilitation, medications and surgery, may significantly improve the quality of life and prolong life expectancy.