Prospects for obesity treatment: MCH receptor antagonists
Collins, C.A.; Kym, P.R.
Current Opinion in Investigational Drugs 4(4): 386-394
2003
ISSN/ISBN: 1472-4472 PMID: 12808876 Document Number: 554925
This article discusses the expression of melanin-concentrating hormone (MCH) and MCH receptors (MCHR) in the brain and other regions of the central nervous system, and their involvement in body weight regulation by triggering an increase in food intake as observed in mouse models. The structure activity relationship of several small molecule MCHR antagonists that have been developed, and its receptor selectivity and in vivo activity are described. Based on these evidences, the use of MCHR antagonists may provide a novel, clinically useful approach for the treatment of obesity.