Influence of dietary lipid on rat liver mitochondrial oxidative phosphorylation & adenosine triphosphatase
Katki, A.G.; Magar, N.G.
Indian Journal of Biochemistry and Biophysics 9(2): 151-155
1972
ISSN/ISBN: 0301-1208 PMID: 4267692 Document Number: 55342
Rats, 4 weeks old, in 8 groups were given for 8 weeks diets containing 15% casein and 10 or 15% safflower oil or liver oil from fish, Galeocerda cuvieri, Eulamina melanoptera or Pristis microdon. In general oxygen consumption of liver mitochondria incubated with alpha -ketoglutarate, malate, glutamate or palmitate as substrate was more and phosphate esterification and P:O ratios were less for rats given fish oils than for rats given safflower oil. With 15% oil in the diet oxidative phosphorylation was less and ATPase activity was greater than with 10% oil. It is suggested that an optimum amount of essential fatty acids is required to maintain the stability of mitochondrial membrane and its ability to effect oxidative phosphorylation.