Molecular factors promoting carcinogenesis and malignant behavior of intraductal papillary mucinous tumors
Ichikawa, Y.; Ueda, M.; Miura, Y.; Kunihiro, S.; Ishikawa, T.; Endo, I.; Sekido, H.; Shimada, H.
Nihon Geka Gakkai Zasshi 104(6): 443-446
2003
ISSN/ISBN: 0301-4894 PMID: 12854490 Document Number: 552495
Many molecular factors related to the carcinogenesis and malignant behavior of pancreatic cancer were identified by investigation of intraductal papillary mucinous tumors (IPMTs). Molecules controlling the G1/S phase, such as p53, p21, p61, and cyclin D1, tumor suppressors including DPC-4, and many other factors such as MUC-1/2 contribute to the promotion of the malignant behavior of IPMTs. They will be important molecular targets for the radical treatment of pancreatic cancer.