Homocysteine and alcohol consumption. An ambiguous relationship and a new paradox
Schlienger, J-Louis.
Presse Medicale 32(6): 262-267
2003
ISSN/ISBN: 0755-4982 PMID: 12610455 Document Number: 552449
The increase in plasma concentrations of homocysteine (Hcy) is a risk factor for cardiovascular diseases. Its determinants are multifactorial, genetic and environmental. Intake of coffee or alcoholic beverages contributes in the increase in Hcy. The alcohol-Hcy interaction is complex and ambiguous. Although chronic alcoholism clearly increases Hcy concentration, the effects of moderate and regular consumption of alcohol are debated in epidemiological studies. Following adjustment of various parameters, it is now admitted that alcohol moderately increases Hcy levels. This is paradoxical since the coronary protective effects of alcoholic beverages has been well established. However, a negative correlation between Hcy and alcoholic beverages has been described in some studies, more especially among beer drinkers. The hypothesis of a reduction in Hcy induced by the beer contents has been described in an interventional study. The vitamins contained in beer, particularly B6, may well be the source of this beneficial effect.