Multi-centric study for the evaluation of the antihypertensive efficacy of hydrochlorothiazide and spironolactone association: comparison between 2 dosages schemes
Fariello, R.; Porcellati, C.; Innocenti, P.F.; Corea, L.; Roncati, G.
La Clinica Terapeutica 105(6): 477-485
1983
ISSN/ISBN: 0009-9074 PMID: 6617110 Document Number: 5521
Eighty patients with mild to moderate essential hypertension were randomized into two groups. One was treated with the usual dosage (25 mg B.I.D.) of a hydrochlorothiazide-spironolactone combination, the other with 50 mg B.I.D. of the same combination. The trial lasted 12 weeks. In addition to standing and lying arterial pressure, the following parameters were assessed: heart rate standing and lying down, blood electrolyte levels, uric acid blood level as well as other hematochemical and hematological parameters. An analogical scale was used to express the physician's appraisal of the therapeutic efficacy and tolerability. No significant differences were found between the two regimens. Blood pressure decreased from the earliest days of treatment and the effect was highly and equally significant for both groups at the end of treatment.
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