Moyamoya and down syndrome: study conducted by meta-analysis
Junqueira, P.A.; Moura-Ribeiro, M.V.L.d.
Arquivos de Neuro-Psiquiatria 60(2-A): 274-280
2002
ISSN/ISBN: 0004-282X PMID: 12068359 Document Number: 551601
We present a clinic-epidemiological study of two patients and meta-analysis (period 1977-2000 ) of the co-morbidity of the Down syndrome (DS) and moyamoya syndrome (MMS). Among the 42 patients listed in this survey, meta-analysis permitted to find the highest number of publications by researchers from Japan and United States, followed by Brazil and Italy; prevalence of cerebrovascular disease in suckling and pre school children; first symptomatology was hemiparesis (78.6%), speech disorders (26.2%); ischemic infarction (76.2%); recurring ischemic episodes (62%); bilateral impairment (83.3%). This analysis led to the conclusion that in the clinic-neurological investigation of DS patients with acute hemiparesis episodes, MMS should be included as the most probable diagnosis.