Moyamoya disease and Down syndrome: case report and review of the literature
de Borchgrave, Vérie.; Saussu, Fçoise.; Depre, A.; de Barsy, T.
Acta Neurologica Belgica 102(2): 63-66
2002
ISSN/ISBN: 0300-9009 PMID: 12161901 Document Number: 540832
We present the case of a 29-year-old woman with Down syndrome who developed bilateral frontal ischemic stroke. Cerebral angiography demonstrated an occlusion of the both supraclinoid internal carotid arteries associated with dilated collateral vessels, consistent with moyamoya disease. We review the clinical and radiological features of moyamoya disease associated with Down syndrome and discuss a few major physiopathologic hypotheses to explain this association.