Cross-talk between immune and skeletal systems
Takayanagi, H.
Nihon Rinsho. Japanese Journal of Clinical Medicine 60(12): 2287-2295
2002
ISSN/ISBN: 0047-1852 PMID: 12510352 Document Number: 551589
Bone destruction in rheumatoid arthritis is characterized as 'the defective control of bone metabolism by the immune system'. During the course of our study to investigate the mechanism of arthritic bone destruction, we have explored a new field called' osteo-immunology'. Here we summarize the regulation of the bone metabolism by signalling cross-talk between RANKL and IFNs, focusing on the T cell-mediated regulation of osteoclastogenesis by IFN-gamma. The better understanding of the interactions between bone and immune cells will provide further insights into the both fields.