A possible cross-talk of retinoic acid- and TPA-driven myeloid differentiation pathways
Zemanová, K.; Smarda, J.
Folia Biologica 44(3): 97-105
1998
ISSN/ISBN: 0015-5500 PMID: 10730850 Document Number: 491561
Retinoic acid (RA) and phorbol esters are important regulators of cellular proliferation and differentiation processes which are capable of arresting growth and inducing differentiation of various leukemic cells. We have studied and compared the effects of these agents on the line of v-myb oncogene-transformed chicken monoblasts BM2. We found that although there are differences in the differentiation kinetics and cell cycle stop points, the differentiation pathways induced by RA and phorbol esters seem to be significantly interconnected.