Retinoic acid effect on the differentiation of blast cells in suspension
Burgaleta, C.; Moreno, T.; Sánchez Godoy, P.
Sangre 34(3): 186-190
1989
ISSN/ISBN: 0036-4355 PMID: 2762980 Document Number: 339410
Cells from three patients showed maturation after incubation with retinoic acid (2 had M-3 AML and 1 had CML-B). Three additional patients showed spontaneous maturation (1 with M-2 and 2 with M-4 AML), and in them cell maturation was also achieved after incubation with retinoic acid and cytosine arabinoside (10 nM). These results confirm different maturation capability of leukaemic cells, as well as the possibility to induce cellular maturation with retinoic acid, especially in patients with acute promyelocytic leukaemia (M-3).