The course of pregnancy in a patient with nail-patella syndrome
Chua, H.L.; Tan, L.K.; Tan, H.K.; Tan, A.S.A.; Choong, H.L.
Annals of the Academy of Medicine Singapore 31(3): 349-352
2002
ISSN/ISBN: 0304-4602 PMID: 12061296 Document Number: 551242
Introduction: The nail-patella syndrome is a rare autosomal dominant condition with high penetrance. Pregnancy in such a patient is rare and we believe this to be the first report of a live birth occurring in a patient with nail-patella syndrome. Clinical Picture: A 25-year-old patient presented in her first pregnancy with nephrotic syndrome associated with characteristic bone abnormalities and nail dysplasia and was later diagnosed to have nail-patella syndrome. In her second pregnancy, the course of her pregnancy was complicated by further deterioration of renal function with superimposed pre-eclampsia resulting in early delivery at 28 weeks. Conclusion: Such pregnancies should be regarded as high risk and managed jointly with the renal physician in a tertiary care centre to ensure an optimal outcome to the mother and baby.