Mg++SO4 treatment improves the hemodynamics following the acute myocardial ischemia and reperfusion
Karapinar, K.; Ulus, A.T.; Kaplan, S.; Tütün, U.; Saritas, A.; Aksöyek, A.; Apaydn, N.; Saritas, Z.; Katircioglu, S.F.
Panminerva Medica 44(2): 129-133
2002
ISSN/ISBN: 0031-0808 PMID: 12032431 Document Number: 551123
Background. The effect of Mg++SO4 on myocardial hemodynamics was investigated in this study. Methods. Twelve dogs were entered in this research. Six dogs received Mg++SO4 and the remaining dogs were considered as controls. The amount of Mg++SO4 that was administered to the animals was 0.15 mmol/kg/hr each. The left anterior descending artery was occluded for a period of 1 hour and the drug was administered during reperfusion. Results. Two hours after reperfusion, cardiac output was 1275+-50 ml/min in the control group and 1475+-25 ml/min in the Mg++SO4 group (p<0.05), pulmonary capillary wedge pressure was 18+-3 mmHg in the control group and 12+-2 mmHg in the Mg++SO4 group. Conclusions. In this study it was shown that Mg++SO4 usage after 1 hour arterial occlusion and 2 hours reperfusion protects the heart from the adverse effects of ischemia/reperfusion and had a better central hemodynamics.