Use of recombinant interleukin-2 in hemorrhagic fever with renal syndrome
Shutov, A.M.; Savinova, G.A.; Kiselev, L.I.; Smirnov, M.N.; Iudintseva, E.V.
Klinicheskaia Meditsina 80(4): 54-57
2002
ISSN/ISBN: 0023-2149 PMID: 12043267 Document Number: 549223
The study enrolled male patients with fever admitted to Ulyanovsk city hospital in November-December 2000 with diagnosis of hemorrhagic fever with renal syndrome (HFRS). The diagnosis was confirmed serologically. 10 patients received recombinant interleukin 2 (rIL-2) in a dose 250,000 IU/day for 5 days. rIL-2 was not given to 10 control patients. Both groups received intravenous prednisolone in a dose 90 mg/day. The response was assessed by minimal diuresis, maximal serum concentrations of urea and creatinine. No lethal outcomes occurred. Minimal diuresis was higher, creatinine and urea levels lower in patients on rIL-2 (647.0 +/- 268.6 mg/day vs 422.0 +/- 198.2 ml/day, p < 0.05; 221.8 +/- 98.1 mcmol/l vs 398.9 +/- 234.9 mcmol/l, p < 0.05; 14.9 +/- 5.1 mcmol/l vs 22.0 +/- 9.0 mmol/l, p < 0.05). Thus, it is evident that rIL-2 reduces symptoms of acute renal failure in HFRS patients. Further investigations of rIL-2 treatment in HFRS are needed.