Spontaneous and induced variability of Streptomyces aureofaciens--chlortetracycline producer
Stryzhkova, H.M.; Kopeĭko, O.P.; Lavrinchuk, V.I.; Bambura, O.I.; Matseliukh, B.P.
Mikrobiolohichnyi Zhurnal 64(4): 19-23
2002
ISSN/ISBN: 0201-8462 PMID: 12436867 Document Number: 549202
Spontaneous and induced variability of Streptomyces aureofaciens strain T[symbol: see text] 633 [symbol: see text] and its variants has been investigated. Correlative relation between the antibiotic formation and colonies morphology was observed. Combined effect of nitrosoguanidine and UV-beams resulted in the obtaining of 27 variants which exceeded activity of strain T[symbol: see text] 633 [symbol: see text] by 30-35% and were stable as to antibiotic biosynthesis during 7-10 generations.