Nuclear factor k B is activated in myelodysplastic bone marrow cells
Sanz, C.; Richard, C.; Prosper, F.; Fernandez-Luna, J.L.
Haematologica 87(9): 1005-1006
2002
ISSN/ISBN: 0390-6078 PMID: 12217815 Document Number: 547828
We describe a significant increase in the DNA binding activity of nuclear factor-kappa B (NF kappa B) in bone marrow cells from patients with myelodysplastic syndrome (MDS) compared with normal donor cells. Furthermore, MDS samples with increased NFkappaB activity consistently showed higher mRNA levels of NFkappaB-regulated cytokines.
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