Histological changes in rat liver during chronic magnesium deficiency
Artizzu, M.; Messier, B.
Revue Canadienne de Biologie 31(1): 31-37
1972
ISSN/ISBN: 0035-0915 PMID: 4111736 Document Number: 54735
Rats were given a synthetic diet deficient in Mg or the same with 0.8 g magnesium sulphate/100 g diet. After 60 days histology of liver in the rats deprived of Mg showed reduced cytoplasmic content and focal necrosis in hepatocytes, increased numbers of Kupffer cells filled with Fe-positive granules and dilatation of blood vessels, especially sinusoids and centrolobular veins. Minor regenerative changes were seen involving hepatocytes but not biliary duct cells.
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