The cardiovascular system of patients with lymphogranulomatosis in long-time remission
Nasibov, O.M.; Pivnik, A.V.; Pasha, S.P.; Sotnikov, V.M.; Shevelev, A.A.; Dmitrieva, M.G.; Molchanova, N.P.; Stoliarova, T.V.
Terapevticheskii Arkhiv 74(12): 68-71
2002
ISSN/ISBN: 0040-3660 PMID: 12577847 Document Number: 545845
To study the cardiovascular system in patients with lymphogranulomatosis (LGM) at prolonged remission. 78 patients received radiation and chemotherapy for lymphogranulomatosis in 1973 to 1995. All the patients underwent electro- and echocardiography (EchoCG), 40 patients had radioisotopic ventriculography (RVG). EchoCG revealed nonspecific changes in the ST segment in 19 (24.3%) patients. Systolic function was decreased vto 46% only in 1 patient. RVG showed a significant reduction in ejection fraction in the experimental group as compared to the control one (55.5 +/- 9.5 and 68.4 +/- 8.0, respectively; p < 0.05). Cardiac disorders revealed in patients with LGM at prolonged remission are mainly insignificant. The risk for cardiac events is not a guide for reducing radiation doses and the intensity of chemotherapy.