Aseptic necrosis of the head of long tubular bones in patients with lymphogranulomatosis
Kanaev, S.V.; Kholin, A.V.; Gershanovich, M.L.; Malinin, A.P.; Semenov, I.I.
Voprosy Onkologii 34(12): 1448-1454
1988
ISSN/ISBN: 0507-3758 PMID: 3218148 Document Number: 317059
The frequency of aseptic necrosis of femoral head was evaluated on the basis of 1066 case histories of Hodgkin's disease of all stages in patients aged 15 and more. The lesions were found in 14 patients (1.3%). Nine of them had received combined treatment for tumor, four--combination chemotherapy alone, and one--radiation alone. All had been given prednisolone. No significant correlation between treatment modality and osteonecrosis development was established. It is suggested that the effect of synergism of such damaging factors as ionizing irradiation, cytostatic drugs and glucocorticoids may be responsible for aseptic necrosis in cases of Hodgkin's disease.