Benzylpenicillin efficacy for neutropenic infection prophylaxis in patients with cancer and postcytostatic neutropenia
Minenko, S.V.; Dmitrieva, N.V.; Chimishkian, K.L.; Zhukov, N.V.; Sokolova, E.N.; Larionova, V.B.; Ptushkin, V.V.
Antibiotiki i Khimioterapiia 47(7): 13-19
2002
ISSN/ISBN: 0235-2990 PMID: 12516191 Document Number: 545407
Evaluation of benzylpenicillin (penicillin G) effect for infection prophylaxis at the oncological patients with severe postcytostatic neutropenia was performed. All the patients with neutrophils levels lower than 0.5 x 10(9)/L were recommended to use antibiotics for infection prophylaxis. Test-group (n = 40) used ciprofloxacin (0.5 g twice daily, per os) combined with benzylpenicillin (1.0 g four times daily, i/v); control group was treated by ciprofloxacin in the same dose only. Combination with benzylpenicillin resulted in statistically significant reduction of infections frequency among oncological patients.