Bovine-derived bone protein extract in the treatment of mandibular Class Ii furcations
Camargo, P.M.; Wolinsky, L.E.; Burgess, A.V.; Wagner, W.R.; Paluk, S.F.; Kenney, E.B.
Compendium of Continuing Education in Dentistry 23(11): 1023-1028; 1030 1032 Passim; Quiz 1042
2002
ISSN/ISBN: 1548-8578 PMID: 12526191 Document Number: 545113
This study was an initial evaluation of the use of a bovine-derived bone protein (BP) extract that contains various growth factors combined with decalcified freeze-dried bone allograft (DFDBA) as regenerative treatment for class II mandibular furcations. Twenty-five patients were divided into 5 groups according to the dosage of BP present per mg of DFDBA to be grafted: (1) 0.00 microgram/mg, (2) 3.13 micrograms/mg, (3) 6.25 micrograms/mg, (4) 12.5 micrograms/mg, and (5) 25.0 micrograms/mg. Surgical exploration of the furcation defects was performed followed by grafting with BP/DFDBA. Results at 6 months showed that attachment gain in the treated furcation areas was greatest in Groups 4 and 5, suggesting that BP has the potential to increase the effects of DFDBA in gaining clinical attachment in mandibular class II furcations.