Microcirculation and hemostasis in influenza and acute viral respiratory infections complicated with pneumonia
Bogomolov, B.P.; Deviatkin, A.V.
Terapevticheskii Arkhiv 74(3): 44-48
2002
ISSN/ISBN: 0040-3660 PMID: 11980121 Document Number: 544512
To study microcirculation (MC), hemostasis and blood viscosity (BV) in influenza and acute respiratory viral infections (ARVI) complicated by pneumonia. Conjunctival biomicroscopy, hemostasis and BV were studied in 232 patients with influenza and ARVI. In 91 of them the disease complicated with acute pneumonia (AP), in 87--with obstructive bronchitis. Irrespectively of the disease course, patients with influenza and ARVI showed intravascular changes in MC system, hypercoagulation, deterioration of fibrinolysis. In convalescence platelet aggregation increased, fibrinolytic blood activity enhanced. In influenza and ARVI complicated with AP intravascular changes and hypercoagulation were most pronounced. In uncomplicated influenza and ARVI accompanied by bronchitis such changes are less severe. BV was the highest in development of AP. MC and hemostatic disorders arising in influenza and ARVI seem to be essential pathogenetic links provoking development of AP. In intravascular aggregation of platelets and red cells, activation of plasmic hemostasis differentiated treatment with desaggregants and anticoagulants are indicated.