Disorders of protein C anticoagulant system in various clinical conditions
Egorova, V.V.; Berkovskiĭ, A.L.; Sergeeva, E.V.; Vasil'ev, S.A.; Karelin, A.A.; Titova, M.I.; Nazarenko, N.A.; Zemlianoĭ, A.B.
Klinicheskaia Meditsina 80(11): 46-50
2002
ISSN/ISBN: 0023-2149 PMID: 12516342 Document Number: 544470
A study was carried out on activity of protein C4 in 73 surgical patients (coagulation test, reagents of company PEHAM). The reduction in activity of protein C was observed in patients with focal liver lesion related to disturbance of protein formation function. This percent of disturbances in protein C system is more often found in patients with vascular pathology. This is explained by the mechanism of its action and implication of vascular endothelium into the process. Disturbances in patients with injury infection are stipulated with activity of C and S proteins and availability of mutant factor V--factor Leiden in patients with diabetes. In the first days after surgical intervention the activity of C protein was much reduced. The obtained results emphasize the importance of research in the system of protein C in surgical patients.