Anti-IGE therapy in asthma
Mehiri Ben Rhouma, N.; Béji, M.; Louzir, B.éc.; Daghfous, J.
La Tunisie Medicale 80(10): 575-580
2002
ISSN/ISBN: 0041-4131 PMID: 12632749 Document Number: 544196
Immunoglobulin E (IgE) is the hallmark of allergic diseases and asthma. Regulating IgE production has been the focus over several years as an important strategy in the treatment of allergic diseases. Recently, nonanaphylactogenic antihuman IgE antibodies have been under clinical evaluation as a therapeutic agent against atopic disease. In asthmatic subjects, the administration of these monoclonal anti-IgE antibody has been shown to reduce plasma IgE levels, reduce early and late phase allergic responses after allergen provocation, improve symptoms and reduce rescue medication. No serious side effects were reported. Thus, the clinical effectiveness of these medications supports the viability of anti-IgE therapy as a potentially effective treatment option for asthma.