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A case of pulmonary thromboembolism after interruption of treatment with unfractionated heparin

Paglia, I.; Carrieri, L.; Oliaro, E.; Bergerone, S.; Mangiardi, L.; Trevi, G.P.

Minerva Cardioangiologica 50(4): 379-382

2002

ISSN/ISBN: 0026-4725
PMID: 12147970
Document Number: 543804
Pulmonary embolism is a quite frequent event (incidence 1/10000/year), and blood stasis, endothelial lesions and coagulation disorders are predisposable factors. Elective treatment is heparin, but the use of this medication is associated with a possible ipercoagulative rebound effect. The case presented is a patient with unstable angina treated with heparin infusion, who developed pulmonary embolism after discontinuation of heparin treatment; the patient didn't present a genetic coagulopathy. Others risk factors have been analyzed and it was observed that discontinuation of heparin infusion could have a predominant role in the development of thrombosis. A MedLine research on the rebound effect of heparin and how to reduce it has been carried out.

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