Anti-inflammatory activity of (o-cresotinate) copper and zinc aquacomplexes
Sokolík, J.; Tumová, I.; Blahová, M.; Bernáthová, M.; Svec, P.
Ceska a Slovenska Farmacie Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti 51(4): 205-207
2002
ISSN/ISBN: 1210-7816 PMID: 12183910 Document Number: 543602
Using rat paw dextran-induced and carrageenan-induced edemas, the antiedematous activities of monohydrate of the diaquatetrakis(o-cresotato)dicopper(II) complex (CuoC) and the diaquabis(o-cresotato)zinc(II) complex (ZnoC) were assayed plethysmometrically. Dihydrate of the diaquabis(salicylato)copper(II) complex (CuS) and the diaquabis(salicylato)zinc(II) complex (ZnS) were used as the standards of comparison. All compounds were administered i.p. in a single dose of 50 mumol/kg body weight (calculated for the RCOO-fragment) 30 min before injecting the irritants. The antidextran/anticarrageenan activities of the species (expressed as a mean edema reduction) were found: CuoC 36/54%--ZnoC 59/65%--CuS 71/52%--ZnS 63/10%. The relationships between the coordination-chemical properties and the biological effects of the corresponding complexes are discussed.