Multilevel regulation of tyrosine hydroxylase. II. Transcriptional regulation
Lenartowski, R.; Goc, A.
Postepy Higieny i Medycyny Doswiadczalnej 56(5): 671-686
2002
ISSN/ISBN: 0032-5449 PMID: 12587431 Document Number: 543396
The tyrosine hydroxylase gene is subject to very precise regulation which aim is to adjust the level of the catecholamines to current stimuli disturbing the homeostasis. The fine tuning of the TH gene activity is realized by the "cross-talk" between the complexes of transcriptional factors with their appropriate regulatory sequences. The transcriptional aspect of that regulation has been reviewed emphasizing the rule of the regulatory sequences in determining cell, tissue and developmental specificity of the TH gene activity.