Role of HLA phenotype in the formation of chronic hepatitis C virus infection
Bondarenko, A.L.; Baramzina, S.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2002(2): 55-57
2002
ISSN/ISBN: 0372-9311 PMID: 12043154 Document Number: 543103
Clinical, biochemical and immunological parameters depending on HLA-phenotypic features were examined in 107 patients aged 18-78 years with chronic hepatitis C virus (HCV) infection. Clinical and biochemical manifestations (asthenic, pain and cytolytic syndromes, hepatomegalia, hyperbilirubinemia, hypoprothrombin- and proteinemia), observed in hepatitis C, were more pronounced in patients having HLA-A30, B35, B41, Cw2, A1-B35, A9-B8. The carriers of B8 and B35 antigens were found to have inadequate immune response in HCV infection, manifested by progressive chronic process in the liver and the development of cirrhosis in patients with such specificity.