Oxidative burden and antioxidant defense system in polymorphonuclear leukocytes of human lung diseases
Sharma, R.N.; Bhardwaj, A.; Behera, D.; Khanduja, K.L.
Indian Journal of Biochemistry and Biophysics 39(2): 124-129
2002
ISSN/ISBN: 0301-1208 PMID: 22896900 Document Number: 543071
Superoxide anion (O2.-) and hydrogen peroxide (H2O2) production was significantly higher in blood neutrophils (PMNs) of patients with lung cancer and non-malignant lung diseases when compared to the controls (p<0.001). Superoxide dismutase (SOD) activity was significantly decreased in PMNs of patients with lung cancer (p<0.001). Similarly, catalase and glutathione peroxidase (GPx) activities were lower in PMNs of lung cancer patients as compared to non-malignant lung diseases and controls. There was an increase in HMP shunt activity as measured by rate of formation of 14CO2 from [1-14C]-glucose in PMNs of lung cancer patients. Modifications in the antioxidant defense system in PMNs of malignant and nonmalignant lung diseases, the changes being more in the malignancy are indicated.