Combined administration of mexidol and anti-arrhythmia agents
Kotliarov, A.A.; Smirnov, L.D.; Smirnova, L.E.; Kurkina, N.V.; Balykova, L.A.; Kariakina, T.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 65(5): 31-34
2002
ISSN/ISBN: 0869-2092 PMID: 12596511 Document Number: 542619
The influence of mexidol on the acute toxicity and electrophysiological effects of nibentan, propranolol, and verapamil was experimentally studied. It was found that mexidol potentiates the ability of propranolol and verapamil to inhibit automatism of the sinus node and suppresses the ability of all the three drugs to increase the refractory period of myocardium. It is suggested that these effects are related to the action of mexidol upon ion channels.