Optimization of dosing of finlepsin and finlepsin-retard in patients with partial epilepsy on the basis of population modeling and drug monitoring
Karlov, V.A.; Bondareva, I.B.; Andreeva, O.V.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 102(6): 15-20
2002
ISSN/ISBN: 1997-7298 PMID: 12101888 Document Number: 542316
Taking into account the drug monitoring data, twenty-six patients with partial epilepsy were treated with finlepsin (carbamazepin) and finlepsin-retard. According to the therapy, the patients were grouped as following: 11 patients were taking finlepsin, 10--finlepsin-retard and 5 were first treated with finlepsin and then, because of the lack of the effect, assigned to finlepsin-retard. The seizures severity was assessed using special seizures severity scale. Better clinical results (remission and reduction of seizures severity) were found in patients treated with finlepsin-retard as compared to those from other groups. Due to monitoring, a remission was reached using the lower finlepsin dosage. The authors confirm individuality of pharmacokinetic parameters, a need in precise individual treatment strategy and a necessity for controlling drug levels in plasma after replacing one form for another.