A pharmacokinetic-dynamic explanation of the rapid onset-offset of rapacuronium
Proost, J.H.; Wright, P.M.
European Journal of Anaesthesiology. Suppl 23: 83-89
2001
ISSN/ISBN: 0952-1941 PMID: 11766253 Document Number: 540289
The rapid onset and offset of rapacuronium can be explained from its pharmacokinetic and pharmacodynamic characteristics. A unique property of rapacuronium is its high value for ke0, indicating a rapid access to the receptor site. The reason for this high ke0 may be related to the low intrinsic potency of rapacuronium, but this is not yet fully clarified.
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