The biological effect of matrix metalloproteinase-1 in epidermal repair
Hu, D.H.; Chen, B.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 15(4): 248-251
2001
ISSN/ISBN: 1002-1892 PMID: 11488037 Document Number: 540197
To review the role of matrix metalloproteinase-1 (MMP-1) in the course of healing in wounded skin. The recent literatures on MMP-1 in skin wound repair were reviewed, which gave the insight into the local effect of MMP-1 during re-epithelialization. Following injury, basal keratinocytes, moving from the wound edge and interact with dermal matrix proteins in the wound bed, were induced to express MMP-1 in a specific space-time pattern. MMP-1 cleaved the collagen, thereby altering its structure and affinity by which the keratinocytes binded it. MMP-1 served a beneficial role in wound healing by facilitating the proliferation and movement of keratinocytes over the collagen-rich wound bed during re-epithelialization. MMP-1 expression of migrating keratinocytes directly influences the re-epithelialization during the course of healing of the wounded skin.