Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells
Fraifeld, V.; Seidman, R.; Sagi, O.; Muradian, K.; Wolfson, M.
Anticancer Research 21(3b): 1975-1978
2001
ISSN/ISBN: 0250-7005 PMID: 11497286 Document Number: 539656
The effect of aurintricarboxylic acid (ATA) on cell growth and proliferative capacity was studied in human ovarian SKOV3 and breast MCF7 carcinoma cells. ATA moderately inhibited cell growth measured by a Neutral red assay after a 24-hour incubation of the cells in the presence of ATA. The ATA-treated cells displayed a markedly decreased capacity to proliferate, as was evident from a colony formation assay. The initial and delayed anti-proliferative effects of ATA were dose-dependent. Together, the results indicated that ATA offers the potential of being recognized as an anti-tumor drug, at least in certain types of cancers.