Analysis of HPV 16 and 18 by in situ hybridization in oral papilloma of HIV+ patients
Paparotto Lopes, S.M.; Meeks, V.I.
General Dentistry 49(4) 386-389; Quiz: 390-391
2001
ISSN/ISBN: 0363-6771 PMID: 12016682 Document Number: 538704
Human immunodeficiency virus (HIV) infection facilitates the development of other infections and lesions including oral papilloma, which has been associated with human papillomavirus (HPV). In analyzing the presence of HPV 16 and 18 by in situ hybridization in oral papillomas from five HIV+ male dental patients, HPV 16 and 18 were observed in 9 of 16 (52.2%) histopathologic specimens. All positive lesions occurred in heterosexual males admitting to oral sexual contact with a female partner (Pearson's correlation; p = 0.0088). These results suggest that oral sexual behavior may be a contributing factor in the presence of HPV 16 and 18 in oral papilloma.