Multiple intracranial and intraspinal meningiomas successively discovered in the absence of neurofibromatosis: 2 cases
Drouet, A.; Guilloton, L.; Pelissou-Guyotat, I.; Saint-Pierre, G.; Ribot, C.; Sindou, M.; Deruty, R.
Revue Neurologique (Paris) 157(10): 1264-1269
2001
ISSN/ISBN: 0035-3787 PMID: 11885519 Document Number: 538692
Multiple meningiomas in different neuroaxial compartments are quite rare. We describe the case of a 44-year-old woman who developed three intracranial meningiomas and 8 years later a T3 dorsal meningioma. Histologically, the frontal and dorsal tumors appeared as benign psammomatouss meningiomas. Both tumors were removed successfully. The second patient was a 31-year-old woman who developed right benign fronto-parietal transitional meningioma. She presented local and spheno-orbital recurrences, then a lombo-sacral lesion. The histological picture worsened from benign to malignant with multiple recurrences. Several mechanisms could account for multiple meningiomas. Such meningiomas could arise from a single primary tumor via subarachnoidal spread of a benign or malignant nature. Alternatively, they could be atypical forms of neurofibromatosis type 2 or tumors with a multifocal origin.