A maternal inherited translocation t (1;22) (q11;p11) in two infertile brothers
Lorda-Sanchez, I.; Tejedor, C.; Sanz, R.; Rodriguez de Alba, M.; de la Fuente, A.; Fernandez, E.; Ayuso, C.; Ramos, C.
Genetic Counseling 12(1): 95-100
2001
ISSN/ISBN: 1015-8146 PMID: 11332984 Document Number: 538055
We report two infertile brothers presenting with azoospermia and oligozoospermia. Cytogenetic studies using G-banding and FISH analysis on lymphocyte cultures revealed an autosomal balanced reciprocal translocation t(1;22)(q11;p11) in both males. The same translocation was found in their mother, but not in a third fertile brother and maternal uncle suggesting that this translocation might compromise the male but not the female gametogenesis in this family.