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The effect of gamma-L-glutamylhistamine analogues on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome P450 system

Nebol'sin, V.E.; Zheltukhina, G.A.; Krzhechkovskaia, V.V.; Kovaleva, V.L.; Evstigneeva, R.P.

Voprosy Meditsinskoi Khimii 47(3): 301-307

2001

ISSN/ISBN: 0042-8809
PMID: 11558312
Document Number: 537230
The influence of gamma-L-glutamylhistamine analogues on the hexenal-induced sleeping, glucocorticoid hormone content in blood plasma and severity of experimental anaphylactic reaction was studied. It was observed that gamma-L-glutamylhistamine analogues caused decrease in the sleeping time and severity of experimental anaphylactic reaction, the elevation of glucocorticoids content in blood plasma. The present results indicate that substances have the wide spectrum of biological activity which depends on the length of the N-acyl radical.

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