Electroconvulsive therapy effective and safe in 55 patients aged 56 years and older with mood disorders and physical comorbidity
Van Waarde, J.A.; Stek, M.L.
Nederlands Tijdschrift Voor Geneeskunde 145(35): 1693-1697
2001
ISSN/ISBN: 0028-2162 PMID: 11561488 Document Number: 536588
To determine the efficacy and safety of electroconvulsive therapy (ECT) in patients aged 56 years and older with mood disorders who had failed to respond to pharmacotherapy. Retrospective, descriptive. Demographic data, illness and treatment characteristics were registered for all patients (age > or = 56 years) treated with ECT in the period 1 January 1998 to 31 December 2000. The efficacy of ECT was evaluated with the 'Montgomery-Asberg depression rating scale' (MADRS) and cognitive side effects were evaluated with the 'Mini-mental state examination' (MMSE). Descriptive statistical methods were used for the analysis. A total of 58 treatments were evaluated in 55 patients with a mean age of 73 years. Most patients had a recurrent depressive disorder with physical comorbidity that did not respond to pharmacotherapy. An average of 12 ECT sessions were given per treatment. In patients where a MADRS score was known before and after ECT, 74% exhibited a significant improvement and 48% reached a complete remission of the depression. Cognitive side effects occurred in 28% of the patients. No serious physical complications were reported. ECT is an essential means of intervention in treating mood disorders of the elderly and should be considered in an earlier phase, especially in patients with physical comorbidity.