Observations on the increased serum levels of YKL-40 in patients with rheumatoid arthritis and osteoarthritis
Morgante, M.; Metelli, M.R.; Morgante, D.
Minerva Medica 92(3): 151-153
2001
ISSN/ISBN: 0026-4806 PMID: 11404723 Document Number: 536284
This study aimed to evaluate the function of glycoprotein YKL-40 in patients with rheumatoid arthritis, erosive osteoarthrosis or coxitis. Serum levels of glycoprotein YKL-40 were assayed using an ELISA method in 40 patients with active-phase rheumatoid arthritis and 20 patients suffering from erosive osteoarthrosis or coxitis. The mean values of YKL-40 were enhanced in all patients with rheumatoid arthritis and arthrosis with higher mean values in erosive osteoarthritis and coxitis (440 ng/ml) compared to rheumatoid arthritis (190 ng/ml). YKL 40 is a local prognostic marker of joint destruction.