Persistent hyperglycemia and hyperinsulinemia in a newborn infant
Tapia Ceballos, L.; Romero Sánchez, J.; Picazo Angelin, B.; Díaz Cabrera, R.; Romero González, J.
Anales Espanoles de Pediatria 54(5): 497-501
2001
ISSN/ISBN: 0302-4342 PMID: 11333480 Document Number: 536003
Management of neonatal hyperglycemia is complex, especially in immature newborns. Etiology is diverse, the most frequent cause being iatrogeny. Neonatal diabetes mellitus is a rare cause of hyperglycemia during the first days of life. Insulin treatment is sometimes required to control the condition. When insulin requirements exceed 2I U/kg/day insulin resistance syndrome should be suspected. We present the case of a newborn infant with Donohue syndrome, or leprechaunism, which is a rare, genetically determined dysmorphic syndrome leading to significant insulin resistance.