Preformulation study of atenolol-containing solutions.. I. the pH dependence of thermostability
Marton, S.; Hatem, A.; Csóka, G.; Rácz, I.
Acta Pharmaceutica Hungarica 71(2): 192-195
2001
ISSN/ISBN: 0001-6659 PMID: 11862668 Document Number: 535480
The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 degrees C. A specific and sensitive HPLC method was adapted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4 with a k value of 1.1 x 10(-3) h-1. The degradation of atenolol followed first-order kinetics at above mentioned conditions.