Antioxidant effect of prostaglandin E2 in the liver alcoholic steatosis
Mal'tsev, A.N.; Levé, O.I.; Sadovnichiĭ, V.V.; Buko, V.U.
Eksperimental'naia i Klinicheskaia Farmakologiia 64(3): 61-63
2001
ISSN/ISBN: 0869-2092 PMID: 11558443 Document Number: 534891
The mechanisms of the antioxidant effect of prostaglandin E2 (PGE2) in cases of chronic alcoholic intoxication were studied. It is shown that PGE2 decreases the production of hydroxyl radicals, lipoperoxides, conjugated dienes, malonic dialdehyde, and carbonyl-containing products of lipid peroxidation. In addition, PGE2 normalizes activity of the liver microsomal monooxygenase system components responsible for the free oxygen radical production.