Sensitivity, specificity and prognostic value of CEA in colorectal cancer: results of a Tunisian series and literature review
Bel Hadj Hmida, Y.; Tahri, N.; Sellami, A.; Yangui, N.; Jlidi, R.; Beyrouti, M.I.; Krichen, M.S.; Masmoudi, H.
La Tunisie Medicale 79(8-9): 434-440
2001
ISSN/ISBN: 0041-4131 PMID: 11774785 Document Number: 534616
In order to determine the sensitivity of CEA in the diagnosis of colo-rectal carcinoma, we studied a series of 48 patients with colo-rectal carcinoma (1992-1996). The sensitivity was at 52% with a reference value of 5 ng/ml and 68.7% for a reference value of 2.5 ng/ml. With a reference value of 5 ng/ml, the sensitivity of CEA was at 37% only for patients with colo-rectal carcinoma at Dukes B stage, 66.6% for patients at stage C and 75% for patients at stage D. The dosage of CEA was carried out with a sandwich immunoenzymatic technique in tube. There is no statistic significant correlation between the pre-operative rate of CEA and the localisation of the tumor and its histologic type; in contrast, it was significantly correlated with the ganglionnary metastasis. A significant relationship between the pre-operative rate of CEA and the Dukes stage was found for a reference value of 10 ng/ml but not for a reference value of 5 ng/ml. We calculated the specificity of the CEA for the cancers of colon and rectum which was at 76.98% with a reference value of 5 ng/ml and 86% with a reference value of 10 ng/ml.