A preliminary result of treatment of progressive multiple sclerosis with autologous peripheral blood stem cell transplantation in China
Ouyang, J.; Ni, X.; Chen, B.
Zhonghua Nei Ke Za Zhi 40(8): 550-552
2001
ISSN/ISBN: 0578-1426 PMID: 11718058 Document Number: 533504
To explore the clinical effect for treatment of progressive multiple sclerosis (PMS) by autologous peripheral blood stem cell transplantation (Auto-PBSCT). One PMS patient was chosen. Peripheral blood stem cells (PBSCs) were mobilized with cyclophosphamide and G-CSF. The CD34+ cells harvesting was performed by continuous flow leukapheresis using a CS3000 plus blood separator. About 12.2 x 10(6) CD34+ cells/kg was collected and preserved at -196 degrees C in liquid nitrogen. PBSCs were reinfused after conditioned by CTX (120 mg/kg) and TBI(10 GY). G-CSF was used to help hematopoietic and immunologic reconstitution. After transplantation the patient received clinical remission, and the abnormal signals of MRI in T1-T4 disappeared, the examination results of the neuro-electrophysiology and T cell subgroup were improved obviously. There was no relapse after 6 months follow up. Auto-PBSCT is effective and safety for PMS. Duration of remission remains to be decided in long-term follow up.