The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen
Watson, S.P.; Asazuma, N.; Atkinson, B.; Berlanga, O.; Best, D.; Bobe, R.; Jarvis, G.; Marshall, S.; Snell, D.; Stafford, M.; Tulasne, D.; Wilde, J.; Wonerow, P.; Frampton, J.
Thrombosis and Haemostasis 86(1): 276-288
2001
ISSN/ISBN: 0340-6245 PMID: 11487016 Document Number: 533160
The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.