The role of PAR family receptors in activation of mast cells in the norm and in acute inflammation in rats
Kiseleva, E.V.; Dugina, T.N.; Gluza, E.; Strukova, S.M.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 87(11): 1527-1533
2001
ISSN/ISBN: 0869-8139 PMID: 11816285 Document Number: 527870
Dose-dependent release of beta-hexoaminidase induced with thrombin was shown to be mediated by the PAR-1. This was further confirmed by means of agonist, antagonist and PAR desensitization. Acceleration of the mast cell mediator secretion by the Xa factor and PAR-2 agonist, was revealed. An increase in the mast cell release induced by thrombin and TRAP-6 was shown in the acute peritonitis model.