Obstructive sleep apnea syndrome and heart failure
Escourrou, P.; Nedelcoux, H.; Monti, A.; Médigue, C.
Revue Neurologique (Paris) 157(11 Part 2): S38-S41
2001
ISSN/ISBN: 0035-3787 PMID: 11924036 Document Number: 532383
Heart failure has an increasing prevalence in middle age adults. The prognosis is very poor even with improved medical therapy and heart transplants. The outcome is related to the neurohumoral disease resulting from heart failure which leads to sympathetic activation that in turns worsens the prognosis. About half of the patients have sleep breathing disorders with variable proportions of central and obstructive apneas. Obstructive apneas are acutely deleterious to ventricular function. On the long run, they may be responsible for a worsening of the disease due to the permanent sympathetic activation seen in obstructive sleep apnea. It is therefore important to detect sleep apnea in patients and to apply a treatment. The best therapeutic procedure in obstructive events appears to be CPAP, provided hemodynamic status is closely monitored.