Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates alpha-adrenergic system. a behavioral study
Skuza, G.; Kolasiewicz, W.
Polish Journal of Pharmacology 53(5): 547-550
2001
ISSN/ISBN: 1230-6002 PMID: 11990076 Document Number: 532350
The obtained results indicate that SA4503, a selective sigma1 receptor agonist, given repeatedly (but not acutely) enhanced the effects of phenylephrine, alpha1-adrenoceptor agonist, and clonidine (stimulating the postsynaptic alpha1-adrenoceptors at high dose) in behavioral models (hyperexploratory activity in rats and aggressiveness in mice, respectively).
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