Present status of WHO's initiative, "Health for all by the year 2000"
Mahler, H.
Annual Review of Public Health 9: 71-97
1988
ISSN/ISBN: 0163-7525 PMID: 3377883 DOI: 10.1146/annurev.pu.09.050188.000443Document Number: 532289
Vasopressin, angiotensin II, epinephrine (alpha 1-adrenergic action) and phorbol 12-myristate 13-acetate (PMA) induce increases in membrane-associated protein kinase C activity concomitant with decreases in the cytosolic activity. The data indicate that the calcium-mobilizing hormones and the active phorbol ester induce translocation from the cytosol to the plasma membrane of this protein kinase. The protein kinase C inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, blocked the translocation to the membrane of this protein kinase induced by PMA and vasopressin.